• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >Metaphyseal Fracture Healing
【2h】

Metaphyseal Fracture Healing

机译：phy骨骨折愈合

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Most of what is known about fracture healing comes from studies of shaft fractures in long bones. In contrast, patients more often have fractures closer to the ends (metaphyses). Here most bone tissue has a spongy, cancellous structure different from the compact bone of the shaft. There is an increasing awareness that metaphyseal fractures heal differently. However, the more easily studied shaft healing has usually been considered as good enough representative for fracture healing in general. My work shows that the biology of metaphyseal healing is more different from shaft healing than was previously known and that this has implications on the effect of various commonly prescribed drugs. First we studied biopsies of healing cancellous bone collected from human donors. We found that the most abundant new bone formation occurred freely in the marrow rather than on the surface of old trabeculae, as described in most literature. There was little cartilage, indicating that the dominant bone formation process is mostly membranous in nature. This is a contrast to the ample cartilage formation commonly found in the well-characterized shaft fracture models. Next we characterized a model that allows for mechanical quantification of regenerating cancellous bone. By contrasting this cancellous healing model with the standard shaft healing model we could demonstrate that the NSAID indomethacin, the glucocorticoid dexamethasone, and the bisphosphonate alendronate all had different effects on the mechanical quality of bone regeneration in shaft and metaphysis; while anti-inflammatory drugs strongly impaired shaft healing, metaphyseal healing was not similarly affected. Alendronate had a positive effect on both models, though the effect was strongest in the metaphyseal model. Taken together these differences shed some light as to the differences in healing biology. The last step (within the boundaries of this thesis) was a characterization of how healing in cortical and cancellous bone differs in terms of immune cell involvement. We could find little difference between the two bone types day 3. However, day 5 an increase in the number of granulocytes could be noted in the cancellous bone while the cortical bone had a higher number of lymphocytes. To conclude, this work furthers our understanding of how metaphyseal healing differs from shaft healing. It has clinical implications as it motivates an increased attention to the site of fracture while contemplating treatment. I hope this thesis can be read as an argument for increased interest in metaphyseal fracture healing.
机译：关于骨折愈合的大多数知识都来自对长骨干骨折的研究。相比之下，患者的骨折往往更靠近末端（（骨）。在这里，大多数骨组织都具有海绵状的松质结构，与轴的紧实骨不同。人们越来越意识到干meta端骨折的愈合方式不同。但是，通常较容易研究的轴愈合通常被认为足以代表骨折愈合。我的工作表明，干phy端愈合的生物学特性与干shaft端愈合的生物学特性比以前已知的要大得多，这对各种常用处方药的疗效都有影响。首先，我们研究了从人类捐赠者那里收集的愈合松质骨的活检组织。我们发现，最丰富的新骨形成自由发生在骨髓中，而不是大多数小梁的表面上。几乎没有软骨，表明主要的骨形成过程本质上主要是膜性的。这与特征明确的干骨折模型中常见的大量软骨形成形成对比。接下来，我们对模型进行了表征，该模型可以对再生的松质骨进行机械量化。通过将这种松散的愈合模型与标准的轴愈合模型进行比较，我们可以证明NSAID消炎痛，糖皮质激素地塞米松和双膦酸盐阿仑膦酸盐对轴和干physi端的骨再生机械质量均具有不同的影响。尽管抗炎药严重损害了轴的愈合，但干meta端的愈合并未受到类似的影响。阿仑膦酸盐对两种模型均具有积极作用，尽管在干phy端模型中这种作用最强。这些差异加在一起为康复生物学的差异提供了一些启示。最后一步（在本论文的范围内）是表征皮质和松质骨的愈合在免疫细胞受累方面如何不同。我们在第3天发现两种骨类型之间几乎没有差异。但是，在第5天，松质骨中的粒细胞数量增加了，而皮质骨中的淋巴细胞数量增加了。总而言之，这项工作使我们对干healing端愈合与轴端愈合之间的区别有了进一步的了解。它具有临床意义，因为它在考虑治疗的同时激发了对骨折部位的更多关注。我希望这篇论文可以作为对干phy端骨折愈合的兴趣增加的论据。

著录项

  • 作者

    Sandberg, Olof;

  • 作者单位
  • 年度 2016
  • 总页数
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号